Cystatin C (Cys-C) Test Kit (Fluorescence Immunoassay)

Application

It is suitable for quantitative determination of cystatin C (Cys-C) in human plasma or whole blood in vitro.

Package

1 test/kit, 5 tests/kit, 10 tests/kit, 25 tests/kit, 50 tests/kit.

Glossary

Cystatin C (Cystatin C, CysC for short), also known as cysteine protease inhibitor C, is a low molecular weight, basic non-glycosylated protein composed of 120 amino acids and a molecular weight of 13kDa. CysC gene is continuously transcribed and expressed in all tissues including kidney, liver, pancreas, intestine, stomach, lung and placenta.

CysC protein has the characteristics of constant production rate and release rate into the blood, can freely pass through glomerular filtration, completely reabsorbed in the proximal convoluted tubule and rapidly metabolized and decomposed, and does not form complexes with other proteins. Its serum concentration is not affected by factors such as inflammation, infection, tumor and liver function, and has nothing to do with gender, diet, body surface area, and muscle mass. It is an ideal endogenous marker to reflect changes in GFR.

Clinical Significance

Cystatin C is released into the blood at a constant rate, completely filtered from the glomeruli, almost completely absorbed in the renal tubules, and excreted only by the kidneys, independent of factors such as gender, diet, inflammation, and body weight. Compared with creatinine, it has the unique advantage of reflecting the glomerular filtration rate. The determination of cystatin C can be used in the diagnosis of children with renal disease, the observation of dynamic conditions in patients with diabetes and renal failure, the observation of renal injury in chemotherapy patients, the observation of renal toxicity of immunosuppressive drugs after renal transplant rejection, the diagnosis of nephrogenic pleural effusion, partial Diagnosis or testing of cardiovascular disease.

Components

The kit consists of cystatin C detection reagent card, detection buffer, ID card and instructions.

Cysteine proteinase inhibitor (cysteine proteinase inhibitor, CPI) was later named cystatin C. Known as γ-trace protein and γ-post globulin, it is widely found in nucleated cells and body fluids of various tissues. It is a low molecular weight, basic non-glycated protein with a molecular weight of 13.3KD and consists of 122 amino acid residues. It can be produced by all nucleated cells of the body, and the production rate is constant. Cystatin c in circulation is only cleared by glomerular filtration, is an endogenous marker reflecting changes in glomerular filtration rate, and is reabsorbed in the proximal convoluted tubule, but is completely reabsorbed Metabolism is decomposed and does not return to the blood. Therefore, its blood concentration is determined by the glomerular filtration rate, and does not depend on any external factors, such as gender, age, and diet. Ideal endogenous marker.

Under normal circumstances, the concentration of Cys-C in serum and plasma is 0.51-1.09 mg/L (reference range). When renal function is impaired, the concentration of Cys-C in the blood changes with the glomerular filtration rate. In renal failure, the glomerular filtration rate decreases, and the concentration of Cys-C in the blood can increase more than 10 times ; If the glomerular filtration rate is normal and the renal tubules are dysfunctional, it will hinder the absorption and rapid decomposition of Cys-C in the renal tubules, increasing the concentration in urine by more than 100 times.

Cys-C is an endogenous substance that basically meets the requirements of an ideal endogenous GFR marker so far. It is a newly developed index for evaluating renal function with good sensitivity and high specificity.

Can be replaced by:

① Complex whole blood testing;

② 24-hour urine collection;

③ Calculation of body surface area and creatinine clearance;

④ The patient is exposed to radioactive substances.

Cystatin C is one of the sensitive indicators for judging the damage of glomerular filtration function. If the patient's renal function has problems, it can judge the degree of renal function damage. Common indicators for judging renal function are creatinine, blood urea nitrogen, etc., urea nitrogen is also affected by the kidneys, such as the influence of diet and the state of the body's metabolic function. If you have a high-protein diet or poor gastrointestinal function, such as inaccurate urea nitrogen when you have diarrhea, creatinine will also be affected by factors such as gender, diet, and muscle content. At this time, you need to more accurately reflect the indicators of kidney damage. Choose Cystatin C was selected because it was only slightly affected by other factors and was an accurate reflection of renal function.

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